Is patent foramen ovale closure indicated for migraine?: patent foramen ovale closure for migraine.

Migraine is a heterogeneous primary headache disorder.1 Migraine prevalence in the general population of the United States is 28 million people (13%) and results in significant costs to the healthcare system.2 Aura consists of 1 or more focal neurological symptoms, such as visual, sensory, or speech disturbances,1 and is present in 30% of migraineurs.3 Cortical spreading depression (CSD), a neuroelectrical phenomenon first described in the rabbit cortex and implicated in the genesis of aura, is characterized by a self-propagating wave of neuronal and glial depolarization followed by hyperpolarization across the cortex.3